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Szakirodalomi Publikációk 4

Szilimarin irodalom:

M1.        Effective Medicinal Plant in Cancer Treatment, Part 2: Review

Wesam Kooti, MSC1, Karo Servatyari, MD1

Journal of Evidence-Based Complementary & Alternative Medicine 2017, Vol. 22(4) 982-995



Cancer is the second cause of death after cardiovascular diseases. With due attention to rapid progress in the phytochemical

study of plants, they are becoming popular because of their anticancer effects. The aim of this study was to investigate the effective

medicinal plants in the treatment of cancer and study their mechanism of action. In order to gather information the keywords

“traditional medicine,” “plant compounds,” “medicinal plant,” “medicinal herb,” “toxicity,” “anticancer effect,” “cell line,” and

“treatment” were searched in international databases such as ScienceDirect, PubMed, and Scopus and national databases such as

Magiran, Sid, and Iranmedex, and a total of 228 articles were collected. In this phase, 49 nonrelevant articles were excluded.

Enhancement P53 protein expression, reducing the expression of proteins P27, P21, NFkB expression and induction of apoptosis,

inhibition of the PI3K/Akt pathway, and reduction of the level of acid phosphatase and lipid peroxidation are the most effective

mechanisms of herbal plants that can inhibit cell cycle and proliferation. Common treatments such as radiotherapy and chemotherapy can cause some complications. According to results of this study, herbal extracts have antioxidant compounds that can induce apoptosis and inhibit cell proliferation by the investigated mechanisms.



M2.        Naturally occurring anti‑cancer compounds: shining from Chinese herba lmedicine

Hua Luo†, Chi Teng Vong†, Hanbin Chen, Yan Gao, Peng Lyu, Ling Qiu, Mingming Zhao, Qiao Liu,   Zehua Cheng - Luo et al. Chin Med (2019) 14:48




Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin,

ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising

compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.



M.3.       The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease

A meta-analysis (PRISMA) of randomized control trials

Sheng Zhong, MD, PhDa,b,c, Yuxiang Fan, MMb,c, Qi Yan, MBBSd, Xingyu Fan, MMb, Bo Wu, MMb, Yujuan Han, MMb, Ying Zhang, MMb, Yong Chen, PhDa, Huimao Zhang, MD, PhDe,∗, Junqi Niu, MD, PhDc - Medicine (2017) 96:49(e9061)



Background: Silymarin (SIL) is an active extraction of the silybum marianum, milk thistle, which is an ancient medicinal plant for treatment of various liver diseases for centuries. This study is to assess the therapeutic effect of SIL in the treatment of nonalcoholic fatty liver disease through meta-analysis.



M.4.       Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary

C Mulrow, V Lawrence, B Jacobs, C Dennehy, J Sapp, G Ramirez, C Aguilar, K Montgomery, L Morbidoni, JM Arterburn, E Chiquette, M Harris, D Mullins, A Vickers, and K Flora.

AHRQ Evidence Report Summaries Current as of September 2000

1.Advances in the use of milk thistle (Silybum marianum).

Post-White J, Ladas EJ, Kelly KM. Integr Cancer Ther. 2007 Jun;6(2):104-9. doi: 10.1177/1534735407301632. PMID: 17548789 Review.

2.Clinical applications of Silybum marianum in oncology.

Greenlee H, Abascal K, Yarnell E, Ladas E. Integr Cancer Ther. 2007 Jun;6(2):158-65. doi: 10.1177/1534735407301727. PMID: 17548794 Review.

3.Future directions for research on Silybum marianum for cancer patients.

Sagar SM. Integr Cancer Ther. 2007 Jun;6(2):166-73. doi: 10.1177/1534735407301566. PMID: 17548795 Review.

4.Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials.

Rambaldi A, Jacobs BP, Iaquinto G, Gluud C. Am J Gastroenterol. 2005 Nov;100(11):2583-91. doi: 10.1111/j.1572-0241.2005.00262.x. PMID: 16279916 Review.

5.Milk thistle (Silybum marianum): an ancient botanical medicine for modern times.

Ross SM. Holist Nurs Pract. 2008 Sep-Oct;22(5):299-300. doi: 10.1097/01.HNP.0000334924.77174.6d. PMID: 18758279 Review. No abs

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